Antioxidant and Antitumorigenic Activities of the Standardized Water Extract From Fruit of <i>Terminalia chebula</i> Retz. var. chebula

Background Terminalia chebula Retz. var. ( T chebula) has been traditionally used as a crude drug for treating various diseases, including skin disorders. This study aimed to investigate the potential antioxidant effects and antitumorigenic activity of an aqueous extract from fruit chebula. Methods The extract's total phenolic content were measured using Folin-Ciocalteu, 1,1-diphenyl-2-picrylhydrazyl (DPPH), ferric reducing power (FRAP) tests, respectively. 2 ´,7 ´-dichlorodihydrofluorescin diacetate assay was employed evaluate ability reduce intracellular reactive oxygen species (ROS) in U-937 human monocytic cell lines which had treated with hydrogen peroxide 30 min. Male ICR mice n = 30, 5 groups) influence on dimethylbenz[a]anthracene (DMBA)/12- O-tetradecanoylphorbol 13-acetate (TPA)-induced carcinogenesis. After 20 weeks treatment extract, tumor incidence, size, number assessed. major compounds determined high-performance liquid chromatography. Statistical analysis performed ANOVA followed by post hoc least significant difference test. Results effectively reduced ROS scavenged antioxidants vitro. IC 50 values DPPH FRAP assays 109.0 ± 14.5 μg/mL 2.39 0.17 μg/mL, Moreover, 4 mg significantly decreased volume, tumors DMBA/TPA-induced tumorigenesis mice. Conclusion ROS, These findings suggest that could be promising therapeutic agent other oxidative stress-related diseases.